I am suprised there is no thread for this one yet.
Miyagawa Atsushi is an 11-year-old boy who is 180 centimeters tall. Since he has a grown-up looking build but acts his age, he has always been running into troubles. On the other hand, his 17-year-old elder sister Atsumi is only 137 centimeters tall. Even though she has a childish looking build, Atsumi takes good care of Atsushi.
This anime comes in short episodes, only 3 minutes or so long each. It's definitely worth a look into.
As of right now there are 6 episode out.