Lots. There are many things which i look out for in a manga, some which ultimately become targets which become my favourites.
1) Storyline
I enjoy original storylines, those that just spell the word "NEW" to my eyes. Though some eventually will follow the clockwork , the author deserves creadit for coming up with such interesting storylines tha may end up having followers.
Such manga include...
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The world god only knows
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Onidere
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Hikaru no Go
2)Comedy
I love laughing. Most of which i find in mangas/animes. The ability to constantly make the readers laugh for me in one of the most important aspects that i look out for in a manga.
Such mangas include
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The world god only knows
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Seto no Hanayome
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Mahou sensei negima
3)Gore/blood/horror
Call me sick, but i enjoy such stuff. By the recent years, i've noticed myelf demanding for more violence and gore. Mangas that focuses in war/killings etc are expected to excel in gore and bloodshed which in turn will get my attention.
Such animes which are shining examples are Umineko no naku koro ni, The higurashi series and Kara no kyoukai. Amazing animes indeed.
Such manga include...
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Umineko no naku koro ni(double credits :D)
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High school of the dead
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Elfen Lied
4)Ecchi
Fanservice! Which (healthy)man can resist the temptation of reading such mangas??
Such mangas include...
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Mahou sensei negima
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High school of the dead
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To-Love-Ru
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Love Hina
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Kurohime
5)The "Wow" factor
Mangas' that have the ability to make people go "WOW"
Such mangas are rare, considering just how many mangas that are followers of previous tittles old or new. The ability make people deem the manga being speacial and note worthy is certain an achievement any author should feel proud of.
Such mangas include...
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Kurohime
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Mahou sensei negima
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The world god only knows
I hope my post helps. :D