Honey select will run "flawless" (there are some bugs that are also present on Windows) on a recent version of wine with dxvk and corefonts installed. Just note that the launcher will not work: Set the resoultion and quality setting (0, 1 or 2) in the UserData/Setup.xml. After that start the Honey Select Unlimited_64.exe directly.
To change the screen used in a multi monitor setup, start the game in window mode and use your windows manager to fullscreen it (in kde right klick on the title bar->additional actions->fullscreen.
But i only modded mine sligtly, nothing that requires ipa so far.
Overall, the games here have no drm and no cheat protection, which is very good for wine support. Only thing that can block you is if the game is using .net in some kind of form (that's why the hs launcher does not work).