Im a bit scared of pre- determinism.
You will do what is predicted, whether you like it or not.
You not accepting it is predetermined.
You dieing is pre-determined.
However, I think a greater rule is that nothing is true.
You are not true until proven by yourself.
However, this proving can not be true unless someone observes you proving that you exist.
Everything related to science starts out as a philosophical query. However, if there are no available means to determine a hypothesis null or significant, then the theory remains baseless.