It will work until the system does anything with system restore (which is part of installation of certain software, like MS SQL, Visual Studio, etc.), then the symlinks will break...
Not recommended. I know, because I
tried this in the past.
Instead what you should do, is install the OS, then customize it in auditing mode with the proper answer file. (To do this, you must pause at the very end, so called OOBE - Out of Box Experience - part of installation where you start to create your user profile).
More details:
Win7: how do I move user folder to a different drive
Users Folder - Move Location in Windows 10