Freelancer
Great game to load up and spend a few hours (or months) building up credits for the next new more powerful ship.
Sid Meier's: Pirates!
Another great "casual" game to load up when you've got nothing to do.
Azure Dreams (GBC/PSX)
A Mystery Dungeon-like RPG where you raise monsters and explore a "giant" tower. (GBC version has a larger dungeon, PSX is more challenging and has more sidequests.)
Actraiser
Sidescrolling action-platformer combined with a town raising sim. The larger the population in your towns the higher your level as well as greater opportunities to find new types of magic and other items.
Brain Lord
An action RPG that requires a good deal of thinking in order to get past some of the puzzles includes a (somewhat) unique method of adding creatures to help fight beside you. Throughout the game you can find various pieces of Jade and each one carries a different type of fairy within it. Some help you fight by either throwing fireballs or orbs of water, some help to heal or revive you others increase your defense or provide light in dark areas so you don't kill yourself by jumping in a pit or onto spikes. You can gather/buy different types of magic and weapons including swords, morningstars, boomerangs and axes. There's no mana or MP for spellcasting, just simply hold the attack button until the magic bar is full and release to fire your favorite spell. (God I love old-school Enix games.)
And plenty of others I can't think of right now.