Which are the Saddest DEATH in Anime, Manga, or Game?

they both kill each other in the end and say sorry and speak these words
"hey, its ok i am sorry i couldn't kill my best friend"

death of the magic fox girl, when they where married and then they sat on that hill playing with small little kitty bells, from now on every time i hear the bells i cry

there was this one ep the name i cannot remember, where this one guy was tricked into selling his body and his girls body to some mad scientists and they where forever cursed and he gave the only cure to the girl he loved and batman like help him put on this little island where was left alone for a month alone and died all by himself

death of Cui-Lin "i was not born to be eaten by demons"
death of the girl that little shota Ren loved i forgot her name, she had like a month to live and they went to beach and ran away from home but she still died cuz she used up all her power to save them

If you actually played the game (which his route appears in and not in the anime) he gets cured of bone cancer and doesn't die

Iriya's death

First Goro lost mother in and his father was only thing to be there. And less than in 5 episodes, his father dies due head trauma. When he finds his fathers corpse lying on floor I was completely stunned. First mother and then father.

T.T Lucy/Nyu. Why did her body have to melt? T.T