I think I'm going to go nuts and post all my thoughts on Soul Eater here :D Warning, there may be spoilers from the manga so be forewarned!
I think my favourite character is Death the Kid, who I can totally empathize with because of his OCD. And yet he manages to kick ass even though he's operating under that handicap.. I love his antics with the Thompson sisters, they make for an amazingly entertaining trio.
Like when he begs Liz to design her eyebrows.. and after she concedes he starts sketching blueprints! xD
I'm also a obsessive fan of SoulxMaka. Just the right mix of trust, tension and Maka Chops. :D I can't understand those who don't like Maka (or her VA for that matter) I think she's a great departure from the usual helpless or secondary female protagonist. And she looks great in her various outfits - uniform, casual, ballroom dress.
And some of my favourite scenes of the series take place in Soul's soul where they work together to achieve soul resonance.
I find the many comments (on videos, blogs, forums) on Chrona's gender to be hilarious. Chrona's gender is intentionally ambiguous! And all those people who argue about it and post scanlated pages are playing right into this huge joke! Ahahaha xD
Just curious, which ED do you prefer?