Possibly. Depends on the personality of the vampire. And tsuyoshiro, while you make some good points, i think one of the problems you mentioned could be solved.
What if you're together for years? The idea of giving up part of your blood over and over doesn't sound too healthy for your body. Not to mention, everytime you have to get bit, and even if you are used it by now it probably leaves some unsightly marks on your body. She could bite the same place over and over again, but dear god after a while that will just look like raw meat.
Well, if you can get blood from another source this problem could be lessened. For example, maybe you could trap small animals like squirrels and let he/or she feed on it instead. Or maybe you could possibly get blood from the butcher possibly get it. Not trying to say your wrong, just saying there are some possible ways to get over that problem. Also, how much the bite mark is effected depends on what kind of fangs we're talking about. If there the ones which have mouths lined with razor sharp teeth, then that could become a problem quickly. But if there the ones with just two fangs, then this wouldn't become a issue too quickly.
But as for peoples reaction, that's something you couldn't really change. For those van helsing types, how problematic they are depends on how just power they have. if there the ones with magic or superpowers, then yes that could be a major problem. However, if they are just normal humans who don't like vampires, then you may stand a fighting chance.